Results
| PMID | 26240828 |
| Gene Name | SLCO2A1 |
| Condition | Endometriosis |
| Association |
Associated |
| Population size | 108 |
| Population details | 108 (78 with endometriosis, 30 healthy control subjects) |
| Age | Endometriosis: 34.2 ± 3.6 years; Control: 35.3 ± 3.8 yrs |
| Sex | Female |
| Infertility type | Female infertility |
| Associated genes | EP3, EP4, FP, PGT, MRP4 |
|
Biomed Res Int. 2015;2015:808146. doi: 10.1155/2015/808146. Epub 2015 Jul 9. Rakhila, Halima| Bourcier, Nathalie| Akoum, Ali| Pouliot, Marc Centre Hospitalier Universitaire de Quebec, Quebec, Canada G1V 4G2 ; Faculte de Medecine, Universite Laval, Quebec, Canada G1V 0A6.| Centre Hospitalier Universitaire de Quebec, Quebec, Canada G1V 4G2.| Centre Hospitalier Universitaire de Quebec, Quebec OBJECTIVE: To investigate the level of expression of prostaglandin receptivity and uptake factors in eutopic and ectopic endometrium of women with endometriosis. DESIGN: Prospective study. SETTING: Human reproduction research laboratory. PATIENTS: Seventy-eight patients with endometriosis and thirty healthy control subjects. INTERVENTION(S): Endometrial and endometriotic tissue samples were obtained during laparoscopic surgery. MAIN OUTCOME MEASURE(S): Real-time polymerase chain reaction assay of mRNA encoding prostaglandin E2 receptors (EP1, EP2, EP3, and EP4), prostaglandin F2alpha receptor (FP), prostaglandin transporter (PGT), and multidrug resistance-associated protein 4 (MRP4); immunohistochemical localization of expressed proteins. RESULTS: Marked increases in receptors EP3, EP4, and FP and transporters PGT and MRP4 in ectopic endometrial tissue were noted, without noticeable change associated with disease stage. An increase in EP3 expression and decreases in FP and PGT were observed in the eutopic endometrium of endometriosis patients in conjunction with the phases of the menstrual cycle. CONCLUSION(S): This study is the first to demonstrate a possible relationship between endometriosis and enhanced prostaglandin activity. In view of the wide range of prostaglandin functions, increasing cell receptivity and facilitating uptake in endometrial tissue could contribute to the initial steps of overgrowth and have an important role to play in the pathogenesis and symptoms of this disease. Mesh Terms: Adult| Biomarkers/metabolism| Endometriosis/diagnosis/*metabolism| Endometrium/*metabolism| Female| Humans| Multidrug Resistance-Associated Proteins/*metabolism| Organic Anion Transporters/*metabolism| Receptors, Prostaglandin/*metabolism| Recept |
|